Therefore, we demonstrated a capture and elimination step prior to affinity selection in order to provide a 'subtractive' effect to the phage population by blocking the undesired binders via binding to other components in the blocking mixture while freeing the positive binders to favour binding towards the relevant antigen.
The majority of these ancestral fold functions promote the modern translation system through binding to other components of the translation apparatus.
These data suggest that the alginate may be degraded or be binding to other components within the model gut (Adiotomre, Eastwood, Edwards, & Brydon, 1990; Wang, Onnagawa, Yoshie, & Suzuki, 2001).
Second, elongin C functions as a component of an E3 ubiquitin ligase by binding to other components, including elongin B and pVHL; this complex determines the specificity for HIF‐1α degradation (Duan et al., 1995; Kim & Kaelin, 2003).
The functions of these domains in relation to cellulose degradation are not known, but possibilities include binding to cellulose, binding to other components of the cellulolytic machinery or interaction with the cell surface.
Given that RIP140 is likely to be a difficult metabolic target to finely tune it would be necessary to screen for compounds that modify the recruitment of RIP140 to specific nuclear receptors at a subset of genes, or alternatively, compounds that can alter its binding to other components of the transcriptional machinery, such as histone modifying enzymes.
The binding of PfSRP19 to PfSRP RNA most likely induces conformational changes in PfSRP RNA that subsequently binds to other components; such as PfSRP54, PfSRP14 and PfSRP9.
The three mutant proteins were transiently expressed in various cellular systems and assayed for expression, processing, localization, and binding to other desmosomal components in comparison to wild-type DSC2a protein.
Because the ICS is thought to mediate binding to other desmosomal components, binding of the DSC2a mutant to the desmosomal plaque proteins PG and PKP2 was tested.
We note that previous investigations (using different cell lines) reported similarly small fractions of PrPC-bound Aβ42 (∼38 %,[ 9] <11 %),[ 35] a result of oligomers binding to other membrane components in addition to PrPC.
We concluded that Vpx might not be present in the HIV-1 PIC, when delivered with the modified HIV-1 particles, since Vpx may require specific binding to other virus-specific components like integrase, MA or RNA.
