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Measured binding may contain some element of cross- or non-specific binding to other cell surface molecules.
In contrast, MUC16 has also been demonstrated to mediate cell adhesion by binding to other cell surface glycoproteins such as galectin-1 and mesothelin [14], [15].
Although our work and that of others [ 2] suggest that PTCH docking peptides specifically target the PTCH receptor on cancer cells, binding to other cell surface receptors cannot be ruled out.
To determine the specificity of LM15 recognition of xyloglucan and to assess its possible binding to other cell wall polymers, LM15 was used to probe glycan microarrays in which large numbers of plant cell wall polysaccharides were assembled [ 28].
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Cells specialized in binding to other cells to assist them in their development are called "nurse cells".
Though binding to other cancer cell lines was observed, these aptamers could lead to identification of biomarkers that are related to cancer.
In order to determine binding to other prostatic cell lines not used throughout screening, cross-binding assays were performed.
Using a semi-quantitative approach similar to that employed for binding of antibodies to other cell surface antigens (Leite et al., 2008; Waters et al., 2008), the binding was scored visually from 0 (no binding) to 4 (very strong binding) by two independent observers.
The presence of these well-known protein-protein interaction domains suggests that Sez-6 function involves binding to other extracellular or cell-surface proteins.
Applying these techniques led us to the conclusion that a significant fraction of CaM is binding to other molecules inside cells both at rest and at elevated Ca2+.
NCAM is a membrane glycoprotein receptor of the immunoglobulin supergene family that mediates cell-to-cell adhesion via homophilic binding to other NCAM molecules and cell-to-substrate adhesion via heterophilic binding (NCAM binding to another ligand or counter-receptor) [ 30].
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