Sentence examples for binding to nicotinic from inspiring English sources
The pancreatic effects are hypothesized to occur as a direct effect of nicotine binding to nicotinic acetylcholine receptors in the developing pancreas, leading to oxidative stress and mitochondrial damage and eventual β-cell apoptosis (Bruin et al. 2007, 2008a, 2008b, 2008c).
Nicotine works by binding to nicotinic cholinergic receptors, which lie on the surface of many cells throughout the body and brain.
The heptapeptide IQTTWSR (IQ), recently reported as inhibitor of the β-amyloid (Aβ) binding to nicotinic acetylcholine receptors (nAChrs), was docked to the homology model of the α7 nicotinic acetylcholine receptor.
Levin, ED, Torry, D, Christopher, NC, Yu, X, Einstein, G, and Schwartz-Bloom, RD. "Is binding to nicotinic acetylcholine and dopamine receptors related to working memory in rats?." Brain Res Bull 43.3 (1997): 295-304.
Acetylcholine acts as a neuronal as well as a non-neuronal signaling molecule through binding to nicotinic (nAChR) and muscarinic acetylcholine receptor (mAChR).
A therapeutic strategy currently in clinical development is vaccination against nicotine, where anti-nicotine antibodies are generated that can sequester the stimulant, preventing it from binding to nicotinic acetylcholine receptors in the brain.
The focus in this work is on in vivo evaluation of 18F-nifene binding to α4β2 nicotinic receptors in rodent brain regions using microPET.
A fourth mechanism, modifications in N's binding to Ms nicotinic acetylcholine receptors, has recently been ruled out [66].
The region between aa 189 and aa 214, proposed to be needed for G binding to the nicotinic acetylcholine receptor (28 ), is relatively conserved in the dataset.
Most of the putative full length long-chain neurotoxins possess the functionally conserved residues such as Lys23, Trp25, Asp27, Phe29, Arg33 and Lys35 that are shown to participate in the binding to Torpedo nicotinic acetylcholine receptor (nAChR) in the case of α-cobratoxin from Naja naja venom [ 18].
Chronic exposure to nicotine has been shown to increase binding to high affinity nicotinic cholinergic receptors in rat brain, but the effect of this treatment on the low affinity α7 nicotinic receptors has been less well characterized.
