Sentence examples for binding to neurons from inspiring English sources

In summary, 3D6 binds plaques and recombinant Aβ 1 40 peptide with high affinity and specificity, mC2 selectively binds Aβ but with lower affinity, while chGantenerumab binds Aβ 1 40 peptide with high affinity, in situ binding indicates non-specific binding to neurons.

Based on previous research, the authors of the study postulated that at the molecular level, painkillers binding to neurons on the periphery of the body cause these two unwanted side effects, while the pain relief occurred at sites in the brain and spinal cord.

Focusing on the downstream effects of Aβ42 oligomer binding to neurons, Susan Catalano's (Cognition Therapeutics, Inc).

Unlike in vitro binding assays, there was no evidence of the chGantenerumab binding to neurons.

As previously shown, 6D11 IgG significantly reduced FITC-A β42O binding to neurons by ~50%.

MAG binding to neurons results in stabilization of the axon, but inhibits further neurite extension (Pan et al., 2005).

The H13,14G substitutions on F-Aβ40 substantially reduced binding to cortical neurons by 65% and to hippocampal neurons by 52% in WT brain slices compared to F-Aβ40 (Figure 2).

There is evidence that PD pathology engages humoral immunity, which is reflected in a detectable level of IgGs in PD brains, binding to dopaminergic neurons in a concentrated distribution at neuronal surfaces or co-localized with α-synuclein on Lewy bodies [41].

Agrin binding to cortical neurons inhibited α3NKA activity, resulting in membrane depolarization and increased action potential frequency [ 50].

After binding to the neuron, the particles transduce millisecond pulses of light into heat, which sufficiently altered the membrane capacitance to elicit action potentials.

It was recently shown that annexin V inhibited L-Aβ42 but not D-Aβ42 binding to cultured cortical neurons yet rescued L-Aβ42 neurotoxicity [44], thus emphasizing the importance of phosphatidylserine in the biophysical binding of Aβ to neurons.