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Advances in antibody engineering technologies have resulted in a number of novel biopharmaceutical formats capable of binding to multiple targets.
For computational methods it is more difficult to study selectivity than activity because selectivity analysis requires the evaluation of compounds binding to multiple targets [2].
The effects of AGS-IV on CVD were supposed to act through binding to multiple targets, for example, by directly binding to the hubs of six modules.
It seems to work by binding to multiple targets, she said, which may slow down the development of resistance.
Combinations of kinase inhibitors, with each potentially binding to multiple targets, may be necessary to inhibit undesirable growth and proliferation signals active in neoplasms [35].
One drug binding to multiple targets may contribute to the overall effectiveness of the treatment, thereby giving rise to the therapeutic polypharmacology.
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Due to their ability of effective binding to multiple target microbes, the antimicrobial peptides (AMPs) have recently received lots of attention as an alternative to antibodies for detecting bacteria.
In vitro experiments such as electrophoretic mobility shift assays showed in all cases tested that binding to multiple target sequences at viral origins of replication takes place with positive cooperativity (15, 21− 21−.
Due to the inherent promiscuity of many molecules in binding to multiple protein targets, plurality of bioactivities must be considered when building models to predict the protein targets or pharmacological activities of small organic compounds.
The biochemical nature of drugs binding to multiple protein targets and its implications on physiology are discussed.
Disorder is also an emerging theme, not only among chaperones but among many hub proteins, which are capable of binding to multiple unrelated targets (Bardwell and Jakob, 2012).
More suggestions(25)
binding to diverse targets
binding to imperfect target
binding to many targets
binding to negative targets
binding to active targets
binding to critical targets
binding to various targets
binding to numerous targets
binding to many targets
binding to various targets
binding to active targets
binding to intracellular targets
binding to multiple peptides
binding to therapeutic targets
binding to multiple alleles
binding to multiple BCRs
binding to negative targets
binding to biological targets
binding to different targets
binding to multiple microchromosomes
binding to genomic targets
binding to diverse targets
binding to multiple ligands
binding to additional targets
binding to other targets
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