Sentence examples for binding to multiple sites from inspiring English sources

An important corollary of this model is that even small differences in binding of homeotic proteins to individual sites could be summed to yield large overall differences in binding to multiple sites.

Binding of RNA to chromatin might also stabilizes high-order chromatin structures by facilitating folding of the chromatin fiber, or long-distance chromatin-chromatin interactions, through its simultaneous binding to multiple sites.

It appears that PTB binding to multiple sites within IRF2 5'UTR leads to a conformational change in the RNA that facilitate binding of other trans-acting factors to mediate internal initiation of translation.

For example, c-MYC occupation is associated with genome-scale alteration of chromatin structure and histone accessibility [13], [93], possibly by stimulation of DNA replication [94] or by binding to multiple sites [24]; while KLF4 regulates histone acetylation [24], [95].

Evidence for ubiquitin-mediated degradation of myosin is mostly indirect, but the E3 ubiquitin ligases MuRF1, which is induced during muscle atrophy, and MuRF3 mediate the ubiquitination of soluble myosin in vitro [8], [9], binding to multiple sites near the head region of MyHC molecules.

In the second pattern, each protein bound strongly alone, and FruA appeared to be binding to multiple sites.

Despite the high-affinity, cooperative binding to multiple binding sites in vitro, no enrichment of this genomic region has been detected in the ChIP-chip assay.

This method yields a metric that quantifies the influence on overall ligand affinity of ligand binding to multiple, distinct sites within a protein binding region.

SP1 activated HB-EGF expression through its binding to multiple transcription sites within the promoter of HB-EGF in OCCC cells.

Analytical SEC clearly revealed that AZD9773 was capable of binding to multiple different sites on TNFα as the molecular size was consistent with approximately 12 Fabs bound per TNFα trimer.

One of them directs tissue-specific expression of yeast GAL4 transactivator, which drives conditional expression of endogenous fly genes via binding to multiple UAS sites of the partner P{EP} transgenes randomly inserted throughout the genome.