Sentence examples for binding to multiple protein from inspiring English sources
The biochemical nature of drugs binding to multiple protein targets and its implications on physiology are discussed.
Due to the inherent promiscuity of many molecules in binding to multiple protein targets, plurality of bioactivities must be considered when building models to predict the protein targets or pharmacological activities of small organic compounds.
(1309) In such cases, the 3D-QSAR techniques must be applied, which must be modified to describe the averaging process for binding to multiple proteins.
The PRD at the carboxy terminus of Synj is capable of binding to multiple endocytic proteins with SH3 domains such as Endo and Dap160 to couple synaptic vesicle fission and uncoating28,29,30,32,33,34.
First, Pan1p acts as a central scaffold for assembly of coat complex at the endocytic sites through its binding to multiple endocytic proteins.
This method yields a metric that quantifies the influence on overall ligand affinity of ligand binding to multiple, distinct sites within a protein binding region.
Notwithstanding, polyclonal antibodies can be inherently more sensitive than their monoclonal counterparts and amplify a low expression signal by binding to multiple epitopes on the target protein [ 26], which was observed in our western blot studies with cells lines (see Figure 1).
Many proteins function by binding to multiple partners.
As exemplified by HIV capsid, small molecule inhibitors can bind to multiple binding sites on the capsid protein and induce or prevent protein interactions and conformational changes.
We speculate that a BH3-only protein other than BIM, BID, PUMA, BAD or NOXA negates the anti-apoptotics in response to NO or that NO promotes binding of multiple proteins to anti-apoptotic BCL-2 members, negating their activity.
Homeodomain-containing proteins may interact with each other to enhance or mediate transcriptional activity, either by the binding of multiple proteins to the same segment of DNA or through the formation of DNA-independent complexes.
