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Exact(7)
Intrinsic disorder is a unique feature that allows proteins to be very dynamic in their structure and to participate in several pathways at the same time through binding to multiple partners via high-specificity and low-affinity interactions play an important role [22], [23].
Many proteins function by binding to multiple partners.
For this case the plasticity of the disordered region clearly enables the binding to multiple partners.
Recent bioinformatics investigations suggest that the majority use of disorder for binding to multiple partners is quite likely to be a general result [ 37- 41].
These and other properties are ideal for proteins that mediate signaling, transcription and coordinate regulatory events, where binding to multiple partners in high-specificity/low-affinity interactions are paramount [ 5].
Overall, these studies show how the plasticity of disordered proteins is used to enable the binding diversity of hub proteins, both for a single disordered region binding to multiple partners and for multiple disordered regions binding to the same partner.
Similar(53)
One of them directs tissue-specific expression of yeast GAL4 transactivator, which drives conditional expression of endogenous fly genes via binding to multiple UAS sites of the partner P{EP} transgenes randomly inserted throughout the genome.
It seems to work by binding to multiple targets, she said, which may slow down the development of resistance.
To further analyze the conformational changes in 14-3-3 14-3-3 14-3-3to its muponple partners, we show the 4-panel induced-fit profile describindingve.
Proteins that interact primarily through one tight binding site allow the clamp to bind multiple partners at once, so that, as suggested in earlier studies, the clamp can be a sliding tool belt on DNA [ 78- 80].
ANCHOR predicts binding regions for about half of this protein, which includes the above region; this could be correct since this protein is known to bind multiple partners.
More suggestions(15)
applicable to multiple partners
binding to many partners
binding to various partners
binding to multiple targets
binding to multiple peptides
binding to phosphorylated partners
binding to cellular partners
binding to multiple alleles
binding to multiple BCRs
binding to different partners
binding to multiple microchromosomes
binding to multiple ligands
binding to other partners
binding to biological partners
binding to multiple sites
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