Sentence examples for binding to multiple BCRs from inspiring English sources

Additionally, this compact display may not allow simultaneous binding to multiple BCRs, preventing the cluster from efficiently effecting B cell stimulation.

Tah1p-Pih1p binding to multiple DII domains regulates Rvb1p/Rvb2p ATPase activity.

Ripperger, J. A. & Schibler, U. Rhythmic CLOCK BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions.

It seems to work by binding to multiple targets, she said, which may slow down the development of resistance.

Many proteins function by binding to multiple partners.

Importantly, we have recently shown in various CML model systems that Gab2 signalling confers resistance to multiple Bcr-Abl selective TKIs [ 9].

On the other hand, the interaction between CrkL and Bcr-Abl increased in Abi1 silenced cells, suggesting that CrkL and Abi1 compete for their binding to Bcr-Abl.

Several of these amino acid substitution mutations directly abrogate imatinib binding to Bcr-Abl, thereby rendering imatinib ineffective.

Likewise, the Cbl family of E3 ubiquitin ligases may provide a targeting function by simultaneous binding to CIN85 and BCR-associated Syk.

Thus the mechanism of methotrexate binding to DHFR involves multiple steps and protein conformational changes.

Through direct binding to sequences present in Bcr and in other proteins implicated in signaling, the mammalian 14-3-3 14-3-3 14-3-3link sproteinssignaling protein comaynents to mitogenic and celinkycle control pathwayspecific