Sentence examples for binding to many partners from inspiring English sources

Networks linking protein-protein interactions typically involve a few proteins binding to many partners (called hub protein or hubs) and many proteins interacting with just a few partners.

One would therefore predict that decreased tyrosine phosphorylation should diminish c-Cbl's E3 ligase activity as well as its binding to many partners.

Overall, these observations support two previously proposed mechanisms by which ID is utilized in protein-protein interactions: namely, one disordered region binding to many partners and many disordered regions binding to one partner [ 30, 31].

IDPs play crucial roles in protein-protein interaction networks, which generally involve a few proteins binding to many partners (called hub proteins or hubs) and many proteins interacting with just a few partners.

Overall, our initial study suggested two primary mechanisms by which disorder is utilized in protein-protein interaction networks, namely one disordered region binding to many partners and many disordered region binding to one partner.

In fact, it has been shown that although hub proteins can be entirely disordered or contain long IDPRs or be highly structured, they utilize intrinsic disorder for protein-protein interactions via at least two mechanisms: one disordered region binding to many partners or many disordered region binding to one partner.

Recently we studied the detailed structures for a one-to-many example (namely, p53 using its disordered regions to bind to many partners), and we also studied the structures of a many-to-one example (namely, 14-3-3 usinglets single binding site to associate with many different disordered partners having different amino acid sequences).

INPP5B binds to many of the OCRL1-binding partners, although there are some differences, most notably in clathrin binding, which is lacking in INPP5B (7, 29).

However, protein-protein interactions often involve highly flexible elements that can assume many distinct conformations upon binding to different partners.

Many proteins function by binding to multiple partners.

Many signaling molecules regulate their binding to protein partners through tyrosine phosphorylation.