Spy1 binding to its relative Cdk partners has demonstrated unique substrate specificity [ 21], offering the possibility that Spy1 binding to Cdk1 is uniquely required to promote the oncogenic properties of Cdk1.
Extracellular regulated kinases (ERK) 1/2 are activated by phosphorylation in response to various extracellular signals, including the binding of CXCR4 to its unique ligand, CXCL12, [22].
Despite the lack of these structural elements, which are responsible for DNA binding in Pol β, Pol X is able to bind DNA with a very high affinity (26), largely due to its unique binding mode where it uses helix αE in the fingers subdomain, helix αC in the palm subdomain, and the interface of the palm and fingers subdomains to bind DNA (M.-I. Su et al., unpublished results; (26, 27)).
For example, gadofosveset trisodium has a prolonged serum half-life due to its unique binding properties to serum albumin.
The anticoagulant activity of heparin is ascribed to its unique pentasaccharide binding site, which exerts strong and specific binding with antithrombin III (ATIII) to generate a heparin ATIII binary complex.
CPPHA, due to its unique allosteric binding site and pharmacology, has the potential to serve as an important pharmacological tool to further investigate functional selectivity among classes of mGlu5 PAMs.
PCR primers were tested In Silico using BLAT in UCSC to confirm their binding to a unique region of the genome and the absence of polymorphism.
In both structures, the substrate H2O/OH− molecule exhibits binding to the unique Fe site of the C-cluster.
The amino-terminus of CIN85 contains three SH3 domains known to mediate protein protein interactions by binding to unique proline-rich motifs.
MAbs 8H2, 6F12 and 7C7 were tested against different preparations of other fungal antigens and reacted distinctly, suggesting binding to unique epitopes.
