Sentence examples for binding to its targets from inspiring English sources
The sponge binds to the miRNA of interest to prevent the latter from binding to its targets.
It may explain the phenomenon of angiogenic and tumor growth suppression observed in animals treated with exogenous 6a-P peptide, resulting in competition with endogenous VEGF binding to its targets.
Recent reports showed that acetylation of the E. coli response regulator CheY had a negative effect on binding to its targets [47], and that CobB was able to regulate chemotaxis by deacetylation of CheY, shown in vitro and in vivo [48].
This finding suggests a more complex transcription-regulatory network acting upstream of the EWS-FLI1 down-regulated than of EWS-FLI1 up-regulated genes, and raises the question, in how far and in which way EWS-FLI1 directly controls gene regulation by directly binding to its targets.
Hdac6 is necessary for normal Tip60 binding to its targets on chromatin.
Judging from these crystal structures, it does not seem that β-catenin undergoes dramatic structural change upon binding to its targets.
H19 contains multiple let-7-binding sites that sequester let-7 and prevent it from binding to its target mRNA (Kallen et al, 2013).
Bevacizumab is a recombinant, anti-VEGF monoclonal antibody with 6 VEGF-binding residues that binds to VEGF, preventing VEGF from binding to its target, VEGFR-1 and VEGFR-2, on endothelial cells.
Bevacizumab is a recombinant, antivascular epidermal growth factor receptor (VEGF) monoclonal antibody with 6 VEGF-binding residues that binds to VEGF, preventing VEGF from binding to its target, VEGFR-1 and VEGFR-2, on endothelial cells.
Upon binding to its target mRNA, miRNA can activate the Argonaute-catalyzed targeted cleavage of mRNA [ 24]; thus, miRNA predominantly acts to reduce the targeted mRNA [ 25].
PN-1 is an inhibitor of not only prostasin, but also of uPA, tPA, thrombin, plasmin, trypsin [ 48] and matriptase [ 21] and it forms an essentially non-reversible binding to its target protease like most other serpins [ 49].
