Sentence examples for binding to its specific from inspiring English sources

TSLP released from keratinocytes potentiated TRPA1 activity by binding to its specific receptor (TSLPR) on sensory neurons in the skin of AD patients and in mouse models of AD.

Upon EGF binding to its specific membrane receptor at the cellular surface, EGFR undergoes dimerisation and auto-phosphorylation on multiple tyrosine residues, a key event in the activation of downstream signalling cascades.

KGFR plays a key role in the control of epithelial growth and differentiation, carrying out its biological effects in a paracrine way [3] through high affinity binding to its specific ligands, namely keratinocyte growth factor (KGF/FGF7), FGF10 and FGF22 [4].

The C-terminus might become structured upon binding to its specific target.

Humanin mediates its protective effect by binding to its specific receptor or target.

Insulin action begins with binding to its specific receptor, a transmembrane receptor tyrosine kinase.

The NF-κB binds to its specific binding sites on the promoter regions and enhances the expression of IL-8 gene.

CGP 41251 was the most effective and GF 109203X the least effective inhibitor of equilibrium binding of [3H]vinblastine to its specific binding sites, probably P-gp, in MCF-7/Adr cells.

In good agreement with the results reported above for terminally differentiated C2C12 cells, Figure 5B (lane 1) shows that in the absence of NF-Y binding to its target promoters a specific induction of methylated histones (H3K9me3 and H4K20me3) is detectable (lanes 6 and 8, respectively), which corresponds to the absence of the acetylated ones (H3K9ac and PAN-H4ac) (lanes 5 and 7, respectively).

CSF1 acts via specific binding to its high-affinity receptor CSF1R (CD115 antigen), encoded by the c-fms proto-oncogene.

In these experiments, we used a mutant anti-c -fos ODN, as a negative control, because it contained a sequence like the anit-c -fos ODN, but with four dispersed nucleotide substitutions that could interrupt the specific binding to its target c -fos and lost inhibitory capability.