Sentence examples for binding to its response from inspiring English sources

Results: A 9-fold decrease in progesterone receptor binding to its response element was observed in tissues obtained after, compared with before, the onset of labor (P =.0008).

CAR typically forms heterodimers with RXR before binding to its response elements within the 5′-regulatory regions of its target genes (Suino et al. 2004).

We investigated whether MPA regulates the transcriptional activity of cyclin D1 promoter via induction of AP-1 binding to its response element.

Specifically, p53 activates the transcription of genes such as p21 through binding to its response element at the p21 promoter site (38– 40).

These studies indicate that PR recruitment to the region of the cyclin D1 promoter under study would not occur via direct binding to its response elements in the chromatin.

For the chemotactic ligand CCL20, it is found that FOXO1 overexpression increases binding of the active NF- κB dimer, while FOXO1 silencing decreases NF- κB binding to its response element.

In addition, helenalin interacts with RelA to inhibit DNA binding to its cognate response elements and by inhibiting activation of the transcription factor NF-κB [ 7].

We observed a dramatic increase in Myc binding to its target promoters in response to serum stimulation in normal fibroblasts.

Based on the fact that expression of Myc is strongly and rapidly induced by serum stimulation, and the fact that Myc is known to be an important regulator of cell proliferation, we hypothesized that Myc might show changes in binding to its target promoters in response to serum stimulation.

In addition to stabilizing PR in the cytoplasm, HSP90 potentiates PR's hormone-dependent response by binding to its LBD, causing it to adopt an open conformation that allows the hormone to enter and bind.

C5a triggers inflammatory responses by binding to its G-protein-coupled C5a-receptor (C5aR).