Sentence examples for binding to its pocket from inspiring English sources

For instance, the kinetics of capsaicin partitioning into the membrane and binding to its pocket on TRPV1 are still poorly defined.

Therefore, we applied the specific Hsp90 inhibitor geldanamycin (GA), which has been shown to block Hsp90 activity by binding to its ATP pocket [52], [53].

Efforts on discovery of small molecules targeting RXRα have been primarily focused on the molecules that bind to its classical ligand-binding pocket (LBP).

Targeting the kinase activity of Bcr-Abl via competition with ATP for its binding to the kinase pocket is the basis of the therapeutic action of imatinib mesylate (IM), the preferred drug for front-line treatment of CML.

Hence, there have been studies designing compounds for inhibiting DHPS by binding to pterin binding pocket [42].

Thus, contrary to our earlier prediction based on the low resolution negative stain EM map (Snider et al., 2006; El Bakkouri et al., 2010), the LARA domain does not appear to directly block the access of ppGpp to its binding pocket but rather to induce a local conformational change in this pocket reducing ppGpp affinity.

These results suggest that RA's observed effect on PP14 activity is mediated through RA putative receptor and not as a result of its binding to PP14's hydrophobic pocket.

ND1 itself serves as a conduit in the transfer of electrons from ubiquinone to its binding pocket in the Q-module [ 77].

Since IBR2 may mimic these phenylalanine residues when binding to RAD51 through its multimerization pocket, the biological activity of IBR2 will be sensitive to structural variations on its phenylsulphonyl moiety.

Rb down-.regulates type 1 and 2 promoters by binding through its large pocket domain to Brf1-TFIIIB and preventing interactions with TFIIIC and pol III that are presumably required for efficient transcription complex assembly [7] [9].

Eg5 is co-crystallized with several inhibitors bound to its allosteric binding pocket.