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This intrinsically disordered segment in the AB loop apparently represents a molecular recognition feature (MoRF), as it undergoes a disorder-to-order transition and becomes structured upon binding to its partner protein, i.e., the C-terminal tail of GG-SpaD.
It therefore appears that overexpression of Lhp1 from a plasmid interferes with the ability to detect binding to its partner Karyopherin.
This residue has been reported as the essential site for binding to its partner without affecting the binding activity of the unmutated domains [ 20].
The formation of the PDZ dimer does not affect the binding to its partner because the peptide-binding sites of both PDZ domains remain open.
It was shown that, in the T2SS, the N-terminal helical region of XpsE can undergo large structural rearrangements that are crucial for binding to its partner, XpsL.
This feature consists of a short region (on the order of 20 residues) that undergoes a disorder-to-order transition that is stabilized by binding to its partner; this short region is within a segment of disorder.
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Because USP34-CD is a large segment (383 amino acids), it is possible that in addition to the catalytic domain, it also comprises a domain required for the binding to its partners to regulate NF-κB in lymphocytes.
The PID LF mutant has been thought to represent a functionless, inert control for the PID, incapable of inhibiting Pak or binding to its partners such as the Fragile X protein [41].
Based on gel filtration, LZAP has been reported to exist in large molecular weight complexes and the pattern of independent regions of LZAP binding to its partners, as we observed, has been reported and may be critical for formation of large protein complexes containing LZAP [6].
Impairment of DCN binding to its partners due to aberrant DCN degradation is linked to fibrotic diseases and fibrotic wound healing.
Namely, catabolic fragments of human DCN have been identified from scars and fibrotic diseases, and the impairment of DCN binding to its partners due to aberrant DCN degradation has been directly linked to fibrotic wound healing [ 94, 95].
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