Sentence examples for binding to its client from inspiring English sources

HSP90 binding to its client protein may protect against physiological oxidative stress [39], [40].

Recently, GA and 17-AAG have been shown to promote superoxide generation [ 48, 49], but it has been suggested that oxidative stress alone is insufficient to disrupt HSP90 binding to its client proteins [ 48].

In both mammalian and yeast cells, Kar2/BiP binding to unfolded client proteins increases in response to ER stress, reducing its mobility within the ER lumen (Snapp et al., 2006).

It disrupts Hsp90 binding to client proteins by competing with its ATP binding site, exposing them to ubiquitination and proteasomal degradation.

These results further imply that binding to the client may induce the folding of the very unstable Spy variants such as L32P.

The NBD of mtHsp70 possesses a weak intrinsic ATP hydrolyzing activity, whereas the SBD is involved in binding to mitochondrial client proteins (21).

Competitive inhibitors of ATP binding to Hsp90 prevent client maturation and show promise as anticancer agents in clinical trials.

These two homologous proteins display some differences and elicit specific functions, such as differential binding to client proteins [28].

These "Super Spy" variants show tighter binding to client proteins and are generally more unstable than is wild type Spy and show increases in apparent flexibility.

This structural complexity allows Mdj1 and other members of this class of J-proteins to function in diverse roles, by binding to client proteins and "delivering" them to Hsp70 [15,16].

Alternatively, other agents, which have been shown to interfere with HSP90 binding to client proteins, such as histone deacteylase inhibitors, may also prove useful in treating BRCA1-deficient cancers.