Sentence examples for binding to its cellular from inspiring English sources

Our findings are in contrast with earlier studies done on coronavirus MHV-A59 where proteolytic cleavage of envelope glycoprotein on virion surface, before binding to its cellular receptor, is necessary for entry and fusion process [18], [21].

For example, an antibody to PA could prevent this protein from binding to its cellular receptor.

The availability of the three-dimensional structure of E6 allows for the visualization of the potential residues that mediate binding to its cellular protein partners.

Eventually, tacrolimus, which was used to inhibit protein phosphatase activity, has complex and numerous effects on the regulation of calcium cycling in the heart through its binding to its cellular target, the tacrolimus binding proteins.

Moreover, knowledge of the amino acid sequences that direct binding of HR-E6 to its protein partners further contributes to the potential of developing agents that block E6 binding to its cellular targets, resulting in the possible re-sensitization of HPV-infected cells to normal cell-death-inducing stimuli.

This consensus sequence has also been referred to as an LXXLL motif [ 20, 21] to highlight the importance of the three conserved leucines at positions 9, 12, and 13 in facilitating E6 binding to its cellular partners, as substitution of these leucines has been reported to abolish E6/E6-AP interaction [ 7].

The cellular tropism of Ad serotype 5 (Ad5)–based vectors is regulated by the Ad attachment protein binding to its primary cellular receptor, the coxsackie and adenovirus receptor (CAR).

The present study aimed at analyzing the molecular and functional properties of primary Vpr proteins isolated from two infected patients, in terms of binding to its known cellular partners, docking at the NE, cytostatic and proapoptotic activities.

Furthermore, it was reported that C-reactive protein, which reaches very high levels in critical illness, inhibits leptin binding to its receptor and blocks cellular signaling [ 25].

Upon EGF binding to its specific membrane receptor at the cellular surface, EGFR undergoes dimerisation and auto-phosphorylation on multiple tyrosine residues, a key event in the activation of downstream signalling cascades.

A second example of host heterogeneity is the observation that the binding of interferon to its cellular receptor triggers a far more attenuated transcriptional response in African-Americans compared to Caucasians [95].