Sentence examples for binding to its catalytic from inspiring English sources
Syrbactins are cyclic peptide derivatives which are known to inhibit the eukaryotic proteasome by irreversible covalent binding to its catalytic sites.
The majority of MMP-2 inhibitor candidate drugs block the active site of MMP-2 by binding to its catalytic Zn2+ ion through a chelating (hydroxamate, sulphonate etc.) group.
Cyclic AMP activates PRKA by binding to its catalytic subnits.
Furthermore, RAS-GTPs induce the translocation and subsequent activation of phosphatidylinositol 3-kinase (PI3Ks) by binding to its catalytic subunit [ 151].
In contrast, the thioredoxin interacting protein (TXNIP) inhibits Trx by binding to its catalytic site thereby competing with other proteins such as ASK1 resulting in an increased susceptibility to undergo apoptosis.
Inhibition of AChE activity has been used as an indicator of organophosphorus insecticide (OP) exposure because OPs irreversibly inhibit the activity of AChE by binding to its catalytic residue (reviewed by Chen et al. 1999; Farahat et al. 2011).
Thus, unless the binding domain binds to its wall substrate, the catalytic domain will not cleave, offering specificity to most enzymes studied.
Thus, if a designer inhibitor could undergo further reaction after its binding to the catalytic Zn2+ ion, an isoform selective inhibitor might be achieved since the reactivity of the designed compound could be distinguished between HDAC1 and HDAC2.
