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All these findings that relate membrane binding to improved efficiency of the peptides mean that this is a major factor to take into account when rationally designing drugs of this type.
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The ELISA included a sample incubation step under strong acidic conditions (pH 3.5) that allowed to reduce nonspecific binding, to improve inter-assay reproducibility, and to reduce interference from binding proteins.
The goal of the design was to use metal binding to improve the computational design of protein protein interfaces, because metals can form stronger interactions with certain residues than simple protein protein hydrogen bonds or van der Waals contacts.
The Ti6Al4V surface, commonly employed in biomedical prostheses, has been chemically functionalized by non-covalent binding to obtain improved antibacterial responses.
28 However, in combination with transforming growth factor (TGF β, a cytokine expressed at high levels in the placenta, 29 BMP-9 binding to ALK1 improved the angiogenic response of endothelial cells.
Bentonite acted as binding agent to improve the alumina-HA coating, with hope that excellent coating with HA will have a positive effect on subsequent cellular efforts, with alumina responsible for just the scaffold strength.
We recommend that a mechanism be put in place for countries to evaluate and upgrade legally binding pictograms to improve RC.
With a mounting death toll, labor activists are pressuring U.S. brands like Gap to sign onto a binding agreement to improve safety in the country's factories.
KP proved, moreover, to modulate the expression of costimulatory and MHC molecules on murine dendritic cells (DC), after selective binding, and to improve their capacity to induce lymphocyte proliferation [16].
SbAvd-1 was further engineered to decrease biotin binding and to improve steroid specificity.
Today CT and MRI are still mainly used to localize radiotracer binding and to improve SPECT quantification, although both CT and MRI have additional potential.
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