While previous studies and the current data provide strong evidence that multiple mGlu5 modulators do not bind to identical binding sites, it is possible that they interact with overlapping sites that share critical residues.
Derivatives of valerenic acid (VA), i.e. acetoxy valerenic acid (AVA) or hydroxy valerenic acid (HVA), do not allosterically modulate GABA-A receptors, but they bind to identical binding sites [ 1, 4].
Once again, the A-to-G substitution at position 3 in the Y box appears to strengthen DEK binding to the DQA1 Y box in comparison with the DRA Y box; allelic variation in the nucleotide at position 7 in the Y-box sequence (as in DQA1*0501 and in the DR4-associated DRB Y-box sequence) may also mediate subtle differences in DEK binding to otherwise identical sites.
Although MYC binding to transcriptional start sites is identical in different cell types, the resulting expression patterns are cell type-specific.
Gaussian smoothing is necessary because current levels of sequence read coverage lead to large deviations in the number of nucleosomes located at neighboring bps, contrary to the expectation that such nucleosomes have very similar binding affinities because they occupy nearly identical sites.
Subsequent binding to a second identical receptor molecule via binding site 2 results in the active 1 2 ligand receptor complex.
Many of the CSBs consisted of 8 or more bp, and often contained core sequences identical to binding sites for known factors as well as other core sequences that aligned with shorter novel cDTs, suggesting that the longer cDTs may contain core recognition sequences for two or more TFs.
It is currently unclear whether the latter binding site is identical to the tight binding site identified by functional studies [43].
They competed for binding to the enzyme, suggesting that they had a common inhibition mechanism and identical or overlapping binding sites.
The most enriched promoter motif in the 2765 heat up-regulated genes was found to be, CGCGCCCG which, whilst showing some similarity to CAMTA binding sites, was not identical to known promoter motifs.
