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Their binding to hydroxyapatite was measured in vitro.
These drugs act at the site of active bone remodeling by binding to hydroxyapatite, inhibiting osteoclast development and migratory activity.
The increase in uptake of 99mTc-PyP is likely to come from its binding to hydroxyapatite crystals in damaged myocytes as well as its uptake in macrophages coordinating the clearance of damaged tissue.
Bisphosphonates localize to bone by mimicking pyrophosphate and binding to hydroxyapatite in mineralized bone.
Due to their structural similarity to pyrophosphate, a normal component of bone matrix, they are integrated in the bone matrix by binding to hydroxyapatite crystals, resulting in inhibition of osteoclast-mediated bone resorption.
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The polymers contained between 1.7 and 3.1 bisphosphonates per chain and were shown to bind to hydroxyapatite crystals with kinetics similar to free bisphosphonate binding.
BPs bind to hydroxyapatite and rapidly accumulate in bone where they inhibit the mevalonate biosynthetic pathway, thereby preventing the post-translational prenylation of small GTP-binding proteins and inducing apoptosis in osteoclasts.
These compounds are analogues of naturally occurring pyrophosphate (P-C-P) which bind to hydroxyapatite crystals.
Fluoride helps prevent dental decay by binding to the hydroxyapatite crystals in enamel.
All of the dendrimers exhibited more than 80% binding rates to hydroxyapatite (HAP), especially the [G2]-dendrimers (2a and 2b) showed dramatic binding rates (>95%).
The hydrolytically stable polyacrylamide phosphonates with their excellent binding properties to hydroxyapatite make them potential candidates for adhesives.
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