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It is likely that SjIR-1 and SmIR-1 may mimic HIR binding to host insulin on the tegument and play important roles in regulation of glucose uptake in schistosomes.
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Hemagglutinin plays a major role in determining host specificity since it is responsible for viral binding to host cell receptors and penetration of host membranes [5], [6], [7].
There are some examples of PfEMP1 variants where binding to host receptors is localized to a single domain (for example, CIDRα binding CD36 [49] or DBLβC2 binding ICAM-1 [50].
Increased peripheral use of glucose may be due to improved insulin binding to insulin receptors.
These data suggest that GABARAP facilitates localization of insulin vesicles on microtubules, probably through its binding to insulin vesicles and microtubules; thus, GABARAP presents insulin vesicles to KIF5.
Xie, L. et al. Alzheimer's β-amyloid peptides compete for insulin binding to the insulin receptor.
This JNK activation suppresses PDX-1 binding to the insulin promoter and reduces insulin gene expression [24].
Rates r1 – r4 describe insulin binding to the insulin receptor at the plasma membrane.
Another module specifies insulin binding to the insulin receptor and comprises two ODEs.
Anti insulin receptor antibodies can cause diabetes by binding to the insulin receptor, thereby blocking the binding of insulin to its receptor in target tissues.
In that study, insulin aspart was shown to be equipotent to RHI in binding to the insulin receptor [ 135].
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