Sentence examples for binding to duplex sequences from inspiring English sources

An alternative strategy is to couple the component to a DNA recognition agent that is capable of binding to duplex sequences within the nanostructure.

Our results showed that these bisaryldiketene derivatives could selectively recognize G-quadruplex DNA rather than binding to duplex DNA.

Growth inhibition of HT29 cells by C1311 was concomitant with rapid drug accumulation in nuclei and in this context we showed that the compound binds to duplex DNA by intercalation, with likely A/T sequence-preferential binding.

They are lower than those obtained by mass spectrometry for the binding of BOQ1 to telomeric G-quadruplex (5.7 μM) or to model duplex sequences (57 μM) (unpublished data).

This paper follows previous conventions to represent duplex sequences.

Telomeres are associated with proteins, both binding to the duplex and single-stranded telomeric sequences.

Anti-gene ONs (AGOs) act by sequence-specific binding to genomic duplex DNA.

This observation confirms that while EMS exposes the initial specific binding interaction, it does not unmask additional lower-affinity nonspecific binding to the duplex.

This subtle discrimination of hairpins over duplexes by JAZ ZF34 suggests that dsRNA stability influences JAZ RNA interactions, but our results nevertheless confirm that JAZ ZF34 is capable of binding to both duplex and hairpin RNAs.

One possibility is that viral suppressors also inhibit siRNA function by binding to siRNA duplexes [41], [42].

To explore the effect of the 2′-OH groups on dsRBD binding to three duplexes, we analyze the dsRBD binding to minor grooves I and II.