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Bordering the loop are two α-helices which serve to anchor the loop and to communicate the information of Ca2+ binding to distant regions of the molecule.
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Hence, binding of Rpp25 to rDNA loci is independent of that of other protein subunits of RNase P and Pol I. We next scanned the human rDNA transcription units (each is ∼14 Kbp) for binding of protein subunits of RNase P by ChIP analysis using specific primers that correspond to distant regions within these units (see Figure 6A).
Desert dust emitted and transported to distant regions influence on the climate, biogeochemistry and air quality of our planet.
Lung cancer metastasizes to distant regions such as the liver and brain, but rarely metastasizes to the breast.
Conformational changes in this region can be transmitted to distant regions of the molecule and affect interactions with TM.
How does binding in distant regions influence kinase activity?
Using technology to more efficiently deliver education to these distant regions may be a solution.
According to the model, DNA binding sites diffuse rapidly within their local regions, while also gradually diffusing away to more distant regions.
As the DNA-binding sites are located at both tetramer ends, SYCP3 can act as a physical strut to hold distant regions of DNA together.
It is known that chromatin looping can juxtapose genes or enhancers to spatially distant regions.
By binding to regulatory regions alongside certain genes, SIRT1 helps dictate those patterns.
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