Mckittrick, C. R. et al. Chronic social stress reduces dendritic arbors in CA3 of hippocampus and decreases binding to serotonin transporter sites.
We therefore initiated a 3D-QSAR study to develop predictive models for compound binding and identify structural features important for binding to this transporter.
The first cluster represents functions related to molecular binding, such as cation binding, metal ion binding, nucleotide binding and NAD binding, whereas the second cluster represents functions related to different transmembrane transporter activity.
In addition, CQAs are predicted to have different interaction energies with each efflux system: Their preferential binding to the MFS transporter is governed by hydrophobic interactions uniformly found in all solutions (Table 6).
Heinzelmann, G., Bastug, T. & Kuyucak, S. Free energy simulations of ligand binding to the aspartate transporter Glt(Ph).
Tao, Z. et al. Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.
Both epileptic groups presented elevated binding to the dopamine transporter and low tissue content of dopamine and its metabolites.
In addition, monoamine transporters share substrates and high affinity inhibitor compounds (such as mazindol) commonly used to study drug binding to the transporters.
Previous imaging studies in different types of dystonia have mostly shown normal radiotracer binding to striatal dopamine transporters (DAT) and normal or decreased binding to striatal dopamine D2/3 receptors (D2/3 receptors) [3, 4].
Data mining using resources like Metrabase can be employed to understand, for example, transporter function or the promiscuous nature of compounds binding to transporters competitively or non-competitively.
