Sentence examples for binding to different sites from inspiring English sources

It will be interesting to investigate further the role of different regions of Atx1 in modulating interactions since SPF45 and CIC, although binding to different sites, i.e. ULM and AXH, compete with each other [12], [18].

Genes are usually controlled by a combination of multiple transcription factors, or by transcription factor complexes binding to different sites embedded in the genes' regulatory non-coding regions.

GEFs binding to different sites at the surface of the target GTPase do not necessarily have to induce the same conformational changes in switch I/II to promote nucleotide exchange.

These results confirm that the counteracting DOX-induced heart failure effect of TALA partially relies on blocking Kv channels by binding to different sites of 4-AP, which significantly regulate the loss of intracellular potassium and cell shrinkage in response to regulatory volume decrease, thereby preventing cell apoptosis.

We assumed that binding to different binding sites (either within the supposed overlapping multi-binding site of the inner vestibule, or out-of-inner-vestibule binding sites), or preferring different conformation of the binding site should be reflected in the experimentally measurable properties of inhibition.

Another possibility is that Smarca1 and other SWI/SNF factors might facilitate Foxa1/2 binding to different target sites in neurons at distinct phases of their maturation to allow for gene expression through promoting an open chromatin state at these targets.

HPep1 and HPep6 inhibited binding of LPS to LBP and HMGB1 by binding to different target sites on LPS, and further evaluation is necessary to determine whether combined treatment with both peptides can inhibit LPS-mediated TNF-α production to a greater extent than treatment with each peptide alone.

To compare the strength of hPS binding to different CT 4 sites described above, we estimated corresponding free energies of binding (ΔG) based on PMF data (see Methods).

In contrast to NIs, the more heterogeneous class of NNIs inhibits NS5B activity by binding to different allosteric enzyme sites resulting in conformational changes before the elongation complex is established.

Combinatorial regulation by groups of diverse miRNA species binding to different numbers of target sites within a single 3' UTR of a given gene has been hypothesized as a mechanism underlying miRNA-mediated gene repression[ 4].

To assess whether APS and SLE/APS- IgG may be binding to different epitopes on the active site of FXa, we selected different APS (n = 5) and SLE/APS- (n = 5) IgG on the basis of similar FXa binding and examined their individual and combined effects (at a final concentration of 200 μg/ml) upon FXa enzymatic activity.