Sentence examples for binding to different pockets from inspiring English sources

Conversely, we explored the hypothesis that two such moieties can co-exist in the same ligand, binding to different pockets.

These compounds bound to the pocket with an affinity similar to locostatin; however, their side chains allowed for binding to different regions within the RKIP binding pocket.

Binding of such lipophilic compounds to membrane-resident proteins is difficult to measure and interpret because of high backgrounds in the measurements and small populations of membrane-resident receptors (Nadal et al. 2000; Powell et al. 1999), as well as possible binding to different-shaped binding pockets.

Hit compounds were evaluated and categorized according to their ability to bind to different binding sites in the ATP-binding pocket.

Epothilones and paclitaxel compete for the same binding pocket on β-tubulin; however, epothilones and the taxanes bind to different sites on β-tubulin.

Although the P4 pocket of Aq and the P1 pocket of DR4 are similar due to high sequence identity in the binding sites, different amino acids were beneficial in the binding to the different proteins.

To analyse conformational changes in the DH domain on binding we crystallized the DH domain alone in the absence of RhoA (Table 1), revealing a significant movement of the GEF switch region, which adopts an α-helical conformation with Trp itself binding in a different pocket on the first DH domain α-helix.

Likewise, Japrung et al. observed that the combination of two drug classes (pyrimethamine and WR99210) that have different modes of binding to the folate pocket of P. falciparum dihydrofolate reductase helped to curtail the rapid acquisition of resistance mutations.

How the modification can satisfy the binding to the two seemingly quite different pockets is surprisingly interesting and certainly deserves further exploration.

On the basis of binding propensity at the different pockets and inhibitor constants, we ranked these isomers as potential candidates for the HCV inhibition.

This suggests that, while both pharmacophores are competitive inhibitors of NADH-binding, they bind to the pocket in different ways.