Sentence examples for binding to different partners from inspiring English sources

However, protein-protein interactions often involve highly flexible elements that can assume many distinct conformations upon binding to different partners.

That is, the concept behind ELMs is that each ELM uses a common set of amino acids for binding to different partners.

To gain further insight into 14-3-3 14-3-3 14-3-3fferent partners, we compared a pair of 14-3-3 binding peptodifferenttail.

On the other hand, both theoretical and experimental studies over many years suggested that natively unstructured or intrinsically disordered proteins form multi-structure ensembles that present different structures for binding to different partners [ 29- 35].

This intriguing p53 example demonstrates the roles of IDRs in determining multiple specificities associated with the one-to-many binding mode, where remarkable conformational changes enable very distinct surfaces to be formed for binding to different partners.

Nevertheless, we cannot discard its contribution to repression in some contexts or through binding to different partners, as previous experiments have demonstrated the relevance of the Sin3A interaction domain for Cbt's repressive role [ 17].

The TCF/LEF family proteins function as transcription repressors or activators of Wnt-responsive genes by binding to different nuclear partners, Groucho and β-catenin [ 164- 167].

Using a collection of structures currently available in the PDB, a single disordered region of p53 is observed to form a helix, a sheet, and two different irregular structures when binding to four different partners, respectively.

In addition to the BAG domain, BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70.

Third, the possibility exists that, even if many of the observed interactions are functionally important and, by inference, the respective binding sites are subject to purifying selection, the binding sites for different partners tend to overlap such that the number of amino residues in these sites increases only slowly with the increase in the numbers of interactions.

While the focus of this paper is on the roles of disorder in the interactions involving two different hub proteins, the DNA binding domain of p53 presents the opportunity to study structural changes involving one structured region binding to several different structured partners.