Your English writing platform
Discover LudwigExact(2)
Through binding to different integrins, VN may directly interact with endothelial cells and platelets [ 49– 51].
Nonetheless, numerous variations which do not resemble RGD but are capable of binding to different integrins have been described (Ruoslahti 1996).
Similar(58)
Overall, previous results of this mutation with respect to different integrin conformations and binding capacities are inconsistent, varying with the beta subunit.
Each integrin dimer binds to different substrates; however, binding may be redundant among dimers.
Upon ligand binding, different integrins transduce signals that differently influence cell survival, proliferation, cytoskeletal organisation, cell adhesion, and migration.
Most of these activities are known to be stimulated by binding to a number of different integrins via the RGD sequence (αv β3, αv β1, αv β5) or via RGD-independent interactions (α4 β1, α9 β1, and α8 β1).
The AdRGD vector has enhanced binding to αν integrins.
These β3 integrin inhibitors antagonize fibrinogen binding to αIIbβ3 integrins on platelets and ligand binding to αvβ3 integrins on vascular cells.
Additional mechanical unfolding triggers an essential arginine residue, which is required for high affinity binding to integrins, to move to a position far from the integrin binding site.
The binding affinities were determined using isolated receptor binding assays where the different integrins (α5 β1, α v β3, and α IIb β3) were immobilised and [I]echistatin was replaced by increasing amounts of the different peptides tested.
This is different from LMα2 chain binding where there is considerable overlap in binding to dystroglycan and integrins.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com