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We found that this fragment could inhibit VEGF binding to different cell types and block VEGF-induced endothelial cell migration.
Hsp70 is able to modulate the immune system by binding to different cell surface receptors, including Toll-like receptors (TLRs) that are known to activate NF-κB [33], [36], [37], and CD40 leading to the activation of p38 MAP kinase [44].
We therefore tested whether monosaccharides, including fucose, Neu5Ac, and galactose, could competitively inhibit CTB binding to different cell lines.
By simultaneously binding to different cell surface targets, BsAb may result in enhanced binding avidity, leading to preferential (strong) binding to only cells that express both targets but not cells that only express a single target, thus fine-tuning the antibody selectivity [54].
Among the lectins that were observed to bind to these cell lines, four (namely, RCA-I, Triticum vulgaris agglutinin (WGA), Wisteria floribunda agglutinin (WFA) and Sambucus nigra agglutinin I (SNA-I)) were found to show noticeably different extents of binding to different cell lines.
Similar(55)
Given the range of their binding capabilities due to multiple domains that contain many binding sites to different cell adhesion receptors, matricellular proteins are able to direct a multitude of biological processes essential for tumorigenesis such as proliferation, cell adhesion, migration, invasion, angiogenesis and survival (Bornstein and Sage, 2002).
However, there was statistically significant variation in binding to different host cells types.
In biological assays, the antigen-binding activity of the re-natured protein, TfRscFv-GAL4, was confirmed by specific binding to different cancer cells and tumor tissues.
Therefore the two states, PRC-repressed and active, exist separately within a cell (binding to different alleles) or cell population.
It has been demonstrated that NT4 branched neurotensin peptides are much more selective than native monomeric neurotensin in binding to different human cancer cells and tissues and that conjugation to different functional units does not affect its binding properties [ 5, 6].
Using the fold differences in the binding affinity of Apt19S to different cell types that we obtained from the flow cytometry, we filtered a list of membrane proteins according to their expression levels in each cell type tested.
More suggestions(11)
binding to different brain
binding to different protein
binding to different chromatin
binding to different host
binding to different Pb
binding to different target
binding to different chromosomal
binding to different p/t-DNA
binding to different promoter
binding to specific cell
applicable to different cell
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