Sentence examples for binding to develop from inspiring English sources

We wished to identify compounds that inhibit kinetochore-MT binding to develop them into new antimitotic agents.

Specifically, we asked whether the 2-amine could be extended through the cleft gate (between D380 and T359) toward the PHD HD1 interface without losing compound binding, ultimately to develop compounds that interfere with PHD HD1 binding.

I therefore propose to use the distribution of changes in strength of transcription factor binding sites to develop tests for natural selection on regulatory regions where the binding sites have been identified.

That means US negotiators can push in Paris for an agreement that would obligate every nation to have internationally binding obligations to develop climate action plans, report transparently on progress and revise those plans regularly, all without needing new action by Congress.

It is thus possible to take advantage of this putative chloride binding site to develop new types of mGluR agonists.

We have used the binding pair to develop a channelrhodopsin membrane localization assay that is amenable to high-throughput screening for opsin discovery and engineering.

A survey of the literature suggests that the over-exploitation of the hydroxamate function as a zinc-binding group to develop inhibitors might be responsible for this situation.

Therefore, this study highlights for the first time the potential key role of targeting the colchicine-binding site, to develop new treatment modalities for taxane-refractory breast cancer.

First, in the bone marrow, stem cells undergo a series of precursor stages during which they rearrange their immunoglobulin (Ig) genes to generate a wide range of unique antigen-binding specificities to develop into immature/transitional B cells.

Systematic analyses of protein-exposed binding epitopes help to develop privileged templates for library design that address protein family members specifically and selectively.

We used the well-characterized interaction between Anx2 and its cellular binding partner p11 [69] to develop the BiFC assay.