Sentence examples for binding to desensitize cells from inspiring English sources
Receptor internalisation by endocytosis is a common response upon ligand binding to desensitize cells.
Starting from a list of known viral targets, we performed a combinatorial screen to identify siRNA cocktails that could desensitize cells to exogenous RNA.
We hypothesized that mimicking viral immunoinhibition by co-transfecting cells with an siRNA cocktail designed to directly knock down expression of immune-related proteins could desensitize cells to exogenous RNA, and thus enable repeated long-RNA transfection.
TNFR1 shedding and the resultant acute decrease in the number of receptor molecules on the cell surface might transiently desensitize cells to TNF action (Xanthoulea et al, 2004).
Importantly, this phosphorylation of IFNAR1 can be induced by ligand-unrelated stimuli that altogether desensitize cells to IFN (reviewed in (Fuchs, 2013).
MCP-1 accumulation does not desensitize cells and leads to late monocyte recruitment.
TNF-α is known for its ability to desensitize T cells to T-cell receptor activation, and there is increasing evidence that TNF-α contributes to a loss of CD28 expression.
Collectively, these results suggest that a greater amount of intracellular dNTPs or overexpression of RRM2 in RRM2-overexpressing cells is likely to desensitize KB cells to rapamycin-induced autophagy.
Omalizumab is able to capture IgE, down-regulating IgE receptors and preventing IgE binding to its high- and low-affinity receptors, and seems to desensitize mast cells [ 14].
In various mammalian GPCR systems, β-arrestin generally has two major functions that are carried out via binding to stimulated GPCRs [12] [16]: termination of GPCR signaling to G proteins like visual arrestin and involvement in the clathrin-mediated internalization process that removes receptors from the cell membrane to desensitize the cell.
Placental Protein 14 (PP14) is a 28 kDa glycoprotein highly secreted in early pregnancy that is able to desensitize T cell receptor (TCR) signaling and modulate T cell activation.
