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IRF4 functionally cooperates with AP-1 transcription factor heterodimer BATF Jun in binding to composite elements in T cells.
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Likewise, many B-ZIP TFs bind to composite elements containing multiple TF families.
Overrepresentation of TF-binding sites and composite elements (TF site pairs) were computed by the F-Match algorithm and composite module analyst program (Composite Module Analysts) that is implemented in the geneXplain platform (www.genexplain.com).
Cooperative binding of transcription factors to composite genomic elements regulates T helper 17 cell differentiation.
GABPα initially was observed interacting with GABPβ (another ETS protein) to bind a composite element (Batchelor et al. 1998).
Third, the proximity of the MYB and AuxRE binding sites in one of them (IAA19) suggested that ARF7/MYB77 heterodimers may bind the composite elements in the promoter of certain auxin-responsive genes.
Oct-1 might activate the epithelial- specific HPV16 enhancer by stabilizing the binding of a nuclear factor to the composite element, which in turn results in higher levels of enhancer activity[ 33].
This demonstrates that FRα activates FGFR4 promoter by binding to cis-regulatory elements.
Cav-19 and EGFR10 act as transcription factors by binding to cis-regulatory elements of downstream target genes.
The hydration properties of PA enhanced its binding to wet composites whereas the hydrophobic properties of TCP enhanced its binding to dehydrated composites.
Both GRDBD and ERDBD belong to the zinc-finger family of DNA binding proteins and bind to GR regulation elements (GRE 32 and ER regulation elements (ERE 33, respectively.
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