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Caveolin-1 can modulate the turnover of the focal adhesion by binding to components of the focal complex, including the epidermal growth factor (EGF) receptor [ 34- 36].
Functional studies using tissue culture cells have revealed a role for OCRL1 in endosomal trafficking (14, 22, 23) consistent with binding to components of the endocytic trafficking machinery.
Thus, parallel residues from different UBL pathways can utilize distinct mechanisms to dictate interaction selectivity, and specificity can be amplified by barriers that prevent binding to components of different conjugation cascades.
As Numb is capable of binding to components of the endocytosis machinery (Santolini et al, 2000; Dho et al, 2006), it may be involved in the enodocytosis of E-cad.
Target prediction analysis indicated that a number of cycling microRNAs were capable of binding to components of the core clock timing process and, for a subset of these microRNAs, there was an inverse expression pattern with their predicted clock gene targets.
Enrichment in clathrin-coated trafficking intermediates is dependent upon binding to components of the clathrin machinery (clathrin heavy chain and the α-adaptin subunit of AP2) (8, 13– 15), while interaction with the small GTPases Rac1 and Cdc42 likely helps OCRL1 associate with the actin cytoskeleton (7, 16, 17).
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First, it may alter the binding to component of the basal transcription machinery, thus decreasing transcriptional activation.
Nanocrystalline silver is capable of binding to components that may enhance their preparation and antibacterial properties.
We propose that hBD3 enters immune cells and prevents activation of a pro-inflammatory response by specifically binding to component(s) of TLR signaling pathways.
Integrins as transmembrane adhesion receptors are composed of α- and β-subunits and mediate binding of cells to components of the extracellular matrix (ECM).
In the first scenario, dependent on an activation-induced conformational change in the CD3ε subunits, a direct binding of Nck to components of the TCR/CD3 complex was shown.
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