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MicroRNAs are small non-coding RNA molecules that regulate mRNA translation and stability by binding to complementary sequences usually within the 3' un-translated region (UTR).
By binding to complementary sequences (a.k.a.a
RISC binding to complementary sequences on the target mRNA results in transcript degradation or translational repression [ 3].
MicroRNAs (miRNAs) are a type of small noncoding RNA that act as endogenous regulators of gene expression by binding to complementary sequences of target messenger RNA (mRNA).
MiRNA binding to complementary sequences in target mRNAs regulates eukaryotic gene expression at the post-transcriptional level through mRNA degradation or translational repression [ 17, 18].
Let-7 inhibits target gene expression by binding to complementary sequences in the mRNA, which leads to translational repression and mRNA degradation (Roush & Slack, 2008; Fabian & Sonenberg, 2012).
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miRNAs have been shown to control mRNA stability and translation by binding to complementary sequence motives in the target mRNAs[6].
MicroRNAs (miRs) have been shown to negatively regulate gene expression by binding to complementary sequence sites in the 3′-untranslated regions of the mRNAs of protein-coding genes, thereby degrading or blocking the translation of these mRNAs.
Notably, microRNAs (miRNAs), which comprise one of the most abundant classes of genes regulators [ 7], play important regulatory roles in metazoan animals and plants [ 8] by binding to complementary sequence in the 3 untranslated region (3-UTR) of target mRNAs, leading to cleavage or translational repression [ 2, 9].
They can inhibit the expression of specific messenger RNAs by binding to complementary target sequences located in the 3' untranslated region (3'UTR) [1].
Small RNA molecules, that regulate a large fraction of the genome by binding to complementary mRNA sequences leading to post-transcriptional gene silencing.
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binding to complementary sites
binding to genomic sequences
binding to similar sequences
binding to bulged sequences
binding to incorrect sequences
binding to complementary parameters
binding to difficult sequences
binding to phosphorylated sequences
binding to exonic sequences
binding to specific sequences
binding to regulatory sequences
binding to different sequences
binding to identical sequences
binding to unrelated sequences
binding to unspecific sequences
binding to complementary strands
binding to complementary UTRs
binding to complementary regions
binds to complementary sequences
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