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Together, these data clarify an important aspect of the NB phenomenology, namely the possibility that the NB protein coating may be derived from direct calcium or apatite binding to common serum proteins that seemingly are also among the more abundant proteins in the serum.
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In order to extend the serum half-life, a natural albumin ligand (a fatty acid) has been conjugated to small therapeutic peptides resulting in a prolonged serum half-life via binding to patients' serum albumin in vivo.
Qin et al. [106] used spectrometry to determine the influence of the length of the carbon chain of perfluorinated carboxylic acids on the binding to bovine serum albumin.
Further, binding to serum albumin [ 11] and body mass index [ 12] may affect serum concentrations of these substances.
Surface passivation with small organic ligands or polymers is one of the most common strategies to enhance physiological stabilities of inorganic nanoparticles (NPs) and minimize their nonspecific binding to serum proteins.
Tight ruthenium binding to serum albumin was established by joint use of spectroscopic and separation methods.
Fructosamine is produced when blood glucose forms ketoamines by covalently binding to serum proteins (7).
We hypothesized that the long-lasting effect of DHE is most likely due to prolonged binding to receptors, rather than serum half-life.
For example, gadofosveset trisodium has a prolonged serum half-life due to its unique binding properties to serum albumin.
Open image in new window Figure 1 The level of serum Ab binding to homologous Br59-HA and cross-reactivity of serum Ab to 2009pdm H1 and H5.
The mean group antibody reactivities and the standard deviations manifested by the serum IgM and IgG repertoires binding to each antigen served to define common (low variation) and individual (high variation) reactivities.
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