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Moreover, PR spliced variants may also modulate PR-A and PR-B activity indirectly, by competitively binding to common nuclear co-regulatory proteins.
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Mutations in the NLS or enhanced binding to nuclear components may account for pronounced nuclear survivin (Engels et al, 2007).
PIAS3 acts by binding to active nuclear STAT3 (r18, event 57).
PY-NLSs mediate nuclear localization via binding to the nuclear transport protein Kapβ2 [ 16].
Moreover, colloidal gold coated with M118E-NTF2 showed reduced binding to Xenopus oocyte nuclear pores.
The down-regulation by E2 predominantly arose via binding to nuclear ERs.
NF-κB is a cytosolic transcription factor binding to nuclear DNA and activating transcription of target genes.
Both structures serve to mediate binding to nuclear transport proteins.
ATRA exerts its effects on gene transcription by binding to nuclear retinoic acid receptors (RARs) [5].
PR mediates its actions by binding ligands, translocating into the nucleus, and directly binding to DNA or nuclear signaling.
Progestins, like oestrogens, are thought to exert their effects mainly through binding to nuclear receptor proteins.
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