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Moreover, peptides selected for binding to certain receptors bind to several sites on the receptor and activation might occur through conformational changes rather than multimerization [54].
This simple modification dramatically improved selective binding to certain G-quadruplexes.
The initial step in mucosal infection by the herpes simplex virus type 2 (HSV-2) requires its binding to certain glycosaminoglycans naturally present on host cell membranes.
These mutations represent the first example of altering arrestin specificity via enhancement of the arrestin-receptor interactions rather than selective reduction of the binding to certain subtypes.
Only proteins, he explains, were thought capable of carrying out complex functions like, for example, triggering a chain of events inside a cell by binding to certain receptors on its surface.
The FDA-approved drug Bynoe uses is called Lexiscan, and it works by binding to certain receptors, A2A adenosine receptors, on the luminal or outer surface of the BBB.
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Ankyrin-independent-binding proteins that selectively bind to certain isoforms of spectrin provide a potentially important flexibility in cellular localization and time of synthesis of proteins involved in spectrin-membrane interactions.
Due to the fact that certain cell types express more than one PPAR subtype, the question arises what determines PPAR binding to a certain DR1 element in these cells [44].
Although hydrophilic materials can generally reduce nonspecific binding to a certain extent, it is very challenging to achieve ultra-low fouling, which is critical for many biomedical applications, such as medical implants, drug delivery carriers, and biosensors.
Moreover, it has been shown that NAC inhibits Rel A/p50 heterodimers but not p50 homodimers and can inhibit NF-κB binding to only certain variant κB elements which presumably interact with distinct redox sensitive NF-κB binding complexes [ 59].
TGF-β inhibits the expression of MMP-1 and MMP-3 by binding to a certain cell surface receptor complex (TGF-β receptor proteins: TβR I/II/III), thus preventing the breakdown of collagens.
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