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The E1A proteins act by directly binding to cellular regulators that play key roles in controlling gene expression and cell growth.
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MV infects cells after binding to cellular receptors CD150 or nectin-4, expressed on subsets of immune cells or the adherens junctions of epithelial cells, respectively9,10,11.
(A ) Lam4S2 binding to cellular lipids (see Figure 2A ).
This is due to some strong electrostatic bindings to cellular membranes.
Hsp90 has a specialized role in regulating the form and function of diverse client proteins by binding to metastable regulators of cellular signaling and key components of multiprotein complexes (Taipale et al., 2010; Trepel et al., 2010).
JAZ (jasmonate ZIM domain) proteins repress JA signalling by binding to transcriptional regulators such as MYC2.
Similarly, trypsin treatment of the nanosensor coated with cellular membranes abolished AH peptide binding to the cellular membranes but did not affect the binding of a control lipid-binding peptide.
These properties are characteristic of signal transduction induced via ligand binding to the cellular receptor, lipoprotein receptor-related protein.
However, p53 phosphorylation prevents p53 from binding to its negative regulator MDM2 [ 35].
This is expected to better reflect the nature of key cellular regulators.
Our analysis also identifies cellular regulators that may be related to the neuronal lineage.
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