Sentence examples for binding to both targets from inspiring English sources
These bispecific antibody fragments not only retained the antigen-binding capacity of each of the parent antibodies, but also are capable of binding to both targets simultaneously as demonstrated by a cross-linking ELISA.
The mutations in site 3 weakened ANK repeat binding to both targets.
Paolini et al. 4 define an interaction target pair if there is at least a ligand binding to both targets under a certain activity range, while Hu et al. 30 employ a simple definition that two targets are related to each other if they share at least five active compounds.
Two of these guide strands, one targeting each seed, were chosen for experimental testing; each having strong predicted binding to both target genes (Figs. 1b, c).
This bs-diabody is capable of binding to both target receptors and blocking ligand-dependent signalling and cell migration in vitro (Jimenez et al, 2005).
Subsequent work in the myeloblast 32D cell line has shown that tribbles-1 and tribbles-2 induce the proteasomal degradation of C/EBPα and C/EBPβ by promoting their ubiquitination by the E3 ligase constitutively photomorphogenic 1 (COP1) through direct binding to both the targets and the ligase [ 26, 32].
These reactions are assisted by the iron-only hydrogenase-like protein Nar1 (human IOP1) which fulfils an intermediary, so far not well-defined function, by binding to both Nbp35 and the CIA targeting complex (Balk et al., 2004; Song and Lee, 2008).
The investigators then applied dual selection pressure to recombined populations which yielded the combinations that were best suited to binding both targets.
BIN2 phosphorylates BR response transcription factors BRI1-EMS-SUPPRESSOR1 (BES1) and BRASSINAZOLE-RESISTANT1 (BZR1) to influence their subcellular localization [ 16, 17], to target BZR1 for protein degradation [ 18], and to impact both binding to target promoters and transcriptional activity of BES1 [ 12].
The kinase phosphorylates the transcription factors Bri1-EMS-suppressor1 (BES1) and BrassinaZole-Resistant1(BZR1) in order to promote the protein degradation of BRZ1 [ 16], to affect the subcellular localization of BRZ1 and BES1 [ 17, 18] and to affect both binding to target promoters and transcriptional activity of BES1 [ 14].
