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We hypothesized that Atg18 may potentially facilitate Atg9 recruitment to Ref(2 P aggregates by simultaneously binding to both proteins.
Hsp70 appears to mediate the interaction of EndoG with CHIP by binding to both proteins, and thus mediates the subsequent regulation of EndoG by CHIP.
Nonetheless, YC-1 (2) demonstrated strong binding to both proteins indicating its binding site can be located in the catalytic domain, consistent with previous investigations.
PPS may increase the ADAMTS5-2 TIMP-3 affinity by a bridging mechanism, in which its binding to both proteins increases the likelihood of their interaction with each other.
In addition, we tested human and murine type III IFNs (hIL-28A, mIL-28A, and hIL-29) as well as the more distantly related human and murine IL-10 for binding to both proteins.
Under IR-resistant condition, cytosolic Ku70 formed a strong complex with Bax but weakened its interaction with p18-cyclin E, while BCLAF1 knockdown affected Ku70 binding to both proteins in a trend similar to wild-type cells, indicating inhibition of apoptosis in the IR-resistant cancer cells is caused by the naturally suppressed BCLAF1.
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l-Citrulline binding to both protein variants is accompanied by an ordering of the lid.
PPR proteins are known to mediate specific RNA processing events including RNA editing [ 3], transcript processing [ 4], and translation initiation [ 5], and are thus thought to be capable of specific binding to both protein and RNA molecules.
PPR domain containing proteins mediate specific RNA processing events including RNA editing, transcript processing, and translation initiation, and found to responsible for specific binding to both protein and RNA molecules itself.
In these experiments, ZFP592 binding to both GST HESX1 fusion proteins was indistinguishable (Fig. 3D).
Benzene is metabolized to a number of electrophilic species that are capable of binding to both DNA and proteins.
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