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In PHH, a low binding to both clusters was found for p53, p73 and, even more so, p63.
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10.7554/eLife.00592.007 Figure 4. Native α-Syn (tag-free construct) promotes v-vesicle clustering by binding to both synaptobrevin-2 and anionic membranes.
What is the significance of adaptor binding to receptor clusters?
Furthermore, LMB treatment induced a drastic decrease of Nup98-HoxA9 binding to Hox clusters.
According to the heatmap, cluster 4 should contain sequences binding to CHIP 3.1, cluster 21 binders to EEV1‐2.1 and cluster 2 binders to DO.1.
The serum also scored 2 for IgM binding to either clustered or unclustered AChR.
None of those samples that were negative on clustered adult AChR were positive for binding to clustered foetal AChR, and 36/39 of those that were positive bound equally to both forms.
Blinatumomab is monovalent for both CD3 and CD19, which may help to avoid unwanted CD3 signaling induced by receptor dimerization or clustering, or allow for conditional CD3 clustering upon binding to the target antigen, CD19.
CadC variants that mimic the active state of CadC independent of environmental stimuli corroborated the correlation between CadC clustering and binding to the DNA, as did altering the number or location of the DNA-binding site(s) in whole cells.
Based on follow up data he suggested a general model in which unorganized transcription factor binding opposed to clustered binding at promoters would initiate heterochromatin formation.
Ligand receptor binding leads to protein clustering followed by receptor activation (Davis et al, 1994).
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