Sentence examples for binding to both closed from inspiring English sources

It was found that acacetin blocked hKv1.5 channels by binding to both closed and open channels.

To test this prediction, we next performed a perturbation experiment in silico to eliminate the neuronal nSM binding to closed nSyx (closed mode of binding of Munc18-syntaxin) (see Figure 2c).

Therefore the in silico mutant experiment confirmed the prediction that neuronal nSM binding to closed nSyx (closed binding mode of Munc18-syntaxin) may be the key factor in inducing the structural divergence of SM-SNARE network motif in yeast and neurons.

Crystal structures of the closed subunits with and without NADP(H) show no significant structural difference, suggesting that the cofactor binding to the closed subunit corresponds to the lock-and-key model in TtAroE.

It seems possible that the open E. coli ParC structure corresponds to the 'DNA-free' form of topoisomerase IV and that the evident flexibility of the 100-122 loop is necessary to allow DNA binding to the closed enzyme conformation.

The single-site association and dissociation rate constants (k+ and k−) and equilibrium dissociation constant (k+/k− = Kd) for ACh binding to the closed conformation were determined for one mutant construct, αE262L (Fig. 2).

This attractive picture is consistent with the experimental observation that when binding to a closed circular DNA at a high protein/DNA ratio, HMGA1 induces a negative torsional stress which, by accumulation, results in a negative supercoil [53].

Dihydropyridines are proposed to induce allosteric inhibition of channel opening by binding to the closed conformation of CaVs.

In addition, 2D descriptor based clustering was done to differentiate the ligands, binding to closed, semi-open and open conformations of human AK.

This interaction is consistent with the SM protein binding to either a closed or open conformation of the syntaxin.

The Glu379 mutant showed no apparent defect in binding to closed syntaxin using the glutathione-coated plate assay but such an assay would not be at equilibrium due to washing of the plates prior to measurement of binding and so this assay would not necessarily detect changes in equilibrium binding affinity [31].