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Lessons from bacteria have led to the view that higher-order complexes permit cooperative binding to both adjacent and non-adjacent operator sites.
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We also solved the structure of trans-divalent streptavidin bound to biotin-4-fluorescein biotin-4-fluorescein biotin-4-fluorescein to an adjacent biotin-binding showing
We consider a simple theoretical model for two interacting transcription factor (TF) species, searching for and binding to two adjacent target sites hidden in the genomic background.
Phosphorylation of H3 S10 during G2/M has been found to prevent HP1β from binding to the adjacent H3K9me residue.
In the crystal lattice, two molecules form a tandem dimer upon binding to adjacent sites on DNA.
Furthermore, FITC-Ahx-QPIHPNNM showed minimal background binding to adjacent non-adenomatous colon tissue during endoscopy.
As for uPA and tPA, the endocytosis of MMP-2 and MMP-13 involves preliminary binding to adjacent receptors.
Furthermore, if TF binding to adjacent operator sites is cooperative, then response curve steepness would also be affected.
Cumulatively, these results indicate that both PPARγ and C/EBPα are directly involved in the activation of the majority of adipocyte-specific genes and that they cooperate through binding to adjacent sites on DNA.
Both cis-regulatory and trans-regulatory coding variation via MSR variants could affect the degree of pQ β-sheet interdigitation between the pQ tracts of TFs binding to adjacent sites in cis.
Wnts can combine with cell membrane receptors that play a critical role in autocrine regulation and/or participate in paracrine modification by binding to adjacent cell membrane receptors.
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