Sentence examples for binding to appropriate from inspiring English sources

In both cases, β-catenin exercised its activity by binding to appropriate DNA promoter regions.

MicroRNAs (miRs) represent small non-coding RNAs of about 20 to 22 nucleotides, which, upon sequence-specific binding to appropriate mRNAs, repress the translation of the corresponding proteins or induce a subsequent degradation of the miR/mRNA complexes.

A different series of tests may be required to determine these aspects; such tests are likely to be non-conventional in pharmaceutical use, including surface analysis, as well as biological function tests to assure that the manufacturing process produces nanoparticles that are active in cellular uptake, transcytosis (Fig.  3), or binding to appropriate biological materials.

The response is triggered by the activation of the NFkB signaling module as a result of the formation of an activating signal associated with the binding of LPS to appropriate receptors.

This unusual shape prevents ribosomes--the button-shaped organelle that zips along the messenger RNA and strings together amino acids into proteins--from binding to the appropriate piece of RNA.

Activation of the pathway is initialized by an agonist binding to the appropriate GPCR which has greater affinity for the Gs protein.

The predicted CTL epitopes were synthesized and tested by biochemical methods for binding to the appropriate recombinant HLA-I protein, and by IFNγ ELISPOT analyses for CTL immune responses using PBMC from healthy, adult and HLA-typed Danish subjects, assumed to have been exposed to multiple influenza infections during the past.

The optimal activation of NF-κB, allowing its binding to the appropriate promoter regions, requires phosphorylation in the transactivation domain of the p65 protein.

Like the majority of neoplastic cells, HCC secrete an array of inflammatory cytokines that exert their multiple, partially overlapping functions (mitogenic, motogenic, angiogenic) in a para-/autocrine manner via binding to their appropriate receptors.

It is widely assumed that G protein-coupled receptors and among them, the melatonin receptors, share the same structure as rhodopsin in which predicted critical residues for ligand binding to the appropriate binding pocket are located in the transmembrane regions [ 29].

ATF4, pATF6(N), and XBP1-sp then activate transcription of CCAAT enhancer binding protein homologous protein (CHOP) by binding to the appropriate promoter region, and CHOP plays a crucial role in ER stress-mediated apoptosis and in diseases including diabetes, brain ischemia, and neurodegenerative disease [ 32].