Sentence examples for binding to and stabilizing from inspiring English sources
The CUE domain of Cue1p further stimulates ERAD substrate turnover by binding to and stabilizing growing, K48-linked, polyUb chains.
We propose that the FCHo/SGIP class of proteins evolved to promote endocytosis by binding to, and stabilizing the open conformation of AP2.
Meanwhile, we observed that p21 was changed concomitantly with RNPC1, suggesting RNPC1 in part induce cell cycle arrest in G1 via binding to and stabilizing p21 transcript [ 11, 35].
Most heat shock proteins protect cells by binding to, and stabilizing, other molecules in the cell; this prevents these molecules from being damaged or from aggregating and allows them to continue to function as normal.
From this, they suggested that GKRP as well as inhibiting GCK activity, also has a paradoxical role in extending GCK half-life by binding to and stabilizing the enzyme, thus protecting it from degradation (14).
This indicates that these SSB proteins are capable of binding to and stabilizing ssDNA that is created by transient thermal fluctuations that induce short-lived bubbles of melted DNA.
The most obvious way in which Arf1GTP could shift the equilibrium from the closed to the open state is by binding to and thus stabilizing only an open, cargo-binding-competent conformation very similar to that presented here for AP2.
The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures.
The calcium channel binding protein, FKBP12.6 (12.6 kDa FK506-binding protein) binds to RyR2 and stabilizes the closed state of the channel, and has recently been renamed as calstabin 2. 34– 36 Dissociation of FKBP12.6 from RyR2 increases the open probability of the channel.
These chaperones function by binding to the enzyme and stabilizing its fold, allowing it to reach its site of activity, i.e. the lysosome.
Their binding, folding and stabilizing abilities to human telomeric G4 DNA structures were comparatively researched.
