Sentence examples for binding to and stabilization from inspiring English sources

Haass and Selkoe argued that small molecules that can specifically inhibit the formation of Aβ oligomers and/or prevent their binding to and stabilization on neuronal membranes is at the top in the search for an AD therapy [ 11].

The renal filtration and clearance of liraglutide is largely prevented by high binding to albumin and metabolic stabilization.

Thermal shift data provided additional evidence that the compounds were binding to PfCDPK1, and thermal stabilization was found to be well correlated with IC50s, both within and across chemical series.

However, kcat/KM is higher with both substrates for the triple mutant, indicating that binding energy has been diverted from substrate binding to transition state stabilization.

The expression level of BRCA2 is presumably regulated through various mechanisms including transcription, subcellular localization, binding to partners, and protein modification and stabilization.

Mechanistically, RITA disrupts the p53-HDM2 complex by binding to p53 and induces HIPK2 stabilization with consequent phosphorylation of p53 on Ser46.

Furthermore, it is probable that some of the cardioprotective effects of IP are independent of HK2 binding to mitochondria and contact site stabilization.

The authors of this study suggest that, instead of contributing to the direct binding and stabilization of trace metals, the redox state of these cysteine residues contributes to the channel's overall affinity for trace metals, thereby providing an additional means of channel regulation [ 16].

Testosterone and DHT both bind to AR, but DHT is more active, displaying greater binding affinity and stabilization of the AR complex [ 23].

This result implies that Hsp90 binding to SENP3 and the consequent SENP3 stabilization are subject to physiological modulation along with environmental ROS fluctuations.

Binding to DNA promotes folding, stabilization, and protection from proteolysis of the bHLH domain.