Sentence examples for binding to and stabilising from inspiring English sources

The effector protein MAP was anticipated to interfere with mitosis by binding to and stabilising microtubules.

The mode of action is based on binding to and stabilising polymerised microtubule filaments, resulting in a change in the total microtubule mass (if high concentrations of the stabilising agent are present) or microtubule dynamics.

There is recent evidence that ferritin L-chain may have a fundamental role in plaque pathology by binding to and stabilising PEN-2, a functional component of γ-secretase, the enzyme that cleaves APP to generate Aβ [ 103].

Further, the RNA-binding protein HuR (homologue of Elav in Drosophila) has recently been shown to be cleaved in HeLa cells during caspase-mediated apoptosis with the two cleavage fragments binding to and stabilising caspase 9 mRNA, thus promoting apoptosis (von Roretz et al., 2013).

Paclitaxel targets cancer cells mainly by binding to and stabilising microtubules (Schiff et al, 1979), arresting cancer cells in G2/M mitotic checkpoint and subsequently inducing apoptosis via an intrinsic apoptotic pathway (Ferlini et al, 2009).

Tropomyosins (TMs) contribute to actin cytoskeleton integrity by binding and stabilising actin filaments (Lin et al, 1997; Gunning et al, 1998), and decreased expression of tropomyosin 1 (TM1) is characteristic of cellular transformation in a number of cell types (Hendricks and Weintraub, 1981; Cooper et al, 1985; Bhattacharya et al, 1990; Masuda et al, 1996; Wang et al, 1996; Hughes et al, 2003).

Furthermore, YAP1 was recently reported to function as an oncogene by promoting proliferation and survival of breast cancer cells by binding and stabilising the KLF5 (Kruppel-like factor 5) transcription factor through its PPxY motif [ 19].

4EBP1 has recently been implicated in a positive feedback loop by binding and stabilising mTORC1, thereby promoting its activation [ 12].

In contrast, using a microtubule sedimentation assay, we observed that at low nM concentrations, hTpx2 (30 nM, dimer) does enhance the affinity of hKif15 (15 nM, tetramer) binding to GMP-CPP stabilised microtubules when in the presence of the non-hydrolysable ATP analogue AMP-PNP (the fitted Kd increasing ∼twofold from 993 nM to 490 nM; Figure 5B).

All patients are rapidly resuscitated on admission to hospital and stabilised according to a standard protocol.

Paclitaxel induces activation of the spindle checkpoint through suppression of microtubule dynamics by binding to the β-subunit of tubulin and stabilising the microtubules.