Sentence examples for binding to and repressing from inspiring English sources

MicroRNAs (miRNAs) are small (∼22 nt) RNAs that play important roles in gene regulatory networks by binding to and repressing the activity of specific target mRNAs.

Xu et al (2013) reported that Snail1 regulates hepatocellular carcinoma malignancy by binding to and repressing the promoter of the Cezanne2 gene.

MiRNAs usually regulate protein expression by binding to and repressing translation or promoting the degradation of their target mRNAs [ 27, 28].

For example, KLF4 acts as a tumor suppressor by binding to and repressing p53 promoters but activating the promoter of p21, a gene involved in cell cycle inhibition [ 7].

Its expression disables germinal center formation by binding to and thus repressing BCL6 [30] [33].

p53 suppresses the PPP by directly binding to G6PD and repressing its enzyme activity.

HIF-1 α inhibits c-Myc activity by promoting its degradation via the proteasome and by binding to and activating Mxi-1, which represses c-Myc transcriptional activity (Zhang et al, 2007a).

Alternatively, one of the strands of the miRNA can be selectively loaded into the RISC complex, which is responsible for binding to target mRNAs and repressing their expression through degradation or translational inhibition.

Together, our results show that AtVOZs directly regulate MOS3/SAR3, which is required for proper timing of flowering, by binding to its promoter and repressing its expression, and suggest that at least part of AtVOZ activities are exerted through influencing the nuclear pore complex.

miRNAs are specialized forms of ncRNA and consist of small, approximately 22-nucleotide single-stranded RNA molecules that regulate gene expression in cells by directly binding to and either degrading or translationally repressing targets.

Myc often represses transcription by binding to and inhibiting the functions of the transcriptional activator Miz-1 [ 35].